Oh yeah, it’s possible. Heres how:

1. Install FreeTDS.
   emerge freetds on Gentoo.
2. Edit /etc/freetds.conf (or wherever in got dropped) to include something like:

   [yourservername]
     host = your.microsoftsql.com
     port = 1433
     tds version = 7.0
   

   (more info)

3. Try a command line sql query with tsql
4. Install DBD::Sybase using the freetds instructions. On gentoo you can try the /usr/bin/g-cpan.pl perl script.
5. Try some of the sample code to test with.

Now you’ve got access to your Windows SQL database on Linux. KICK ASS!